EVALUATION OF ANTIOXIDANT AND CHEMOPREVE NTIVE POTENTIAL OF M ETHANOLIC EXTRACTS OF LEAF OF AEGLE MARMELOS ATTRIBUTES TOWARDS DUCTAL CARCINOMA STUDIED IN MCF7 CELLS
By: Arirudran, B
.
Contributor(s): Janani, B.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(2).Description: 21-25p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective
:
The objective of the present research work
ha
d been made to evaluate the a
ntioxidant potential along with anti
-cancer
activity
of
methanolic extracts
from
the
leaf
of
A. marmelos
.
Method
s:
Standard methods for antioxidant potential in terms of DPPH and nitric oxide scavenging assay, and
anticancer
activity
in vitro
method
(Cytotoxicity
/MTT assay
and % of cell viability
) by using
MCF7 cell line.
Result
s:
Results of antioxidant efficacy reveal
ed that the IC
50
value for DPPH and nitric oxide scavenging assay was considered to be 62.032%, and
20.69% respectively. The methanolic extract of
A
. marmelos
was found to possess
enhanced
anticancer
potential against MCF7 cells. Cytotoxicity
activity of MCF7 cells
, when treated with methanolic
extract of A. marmelos
, was found to be 43.42% at 25μg
, 52.31% at 50μg,
56.31% at 75μg,
58.38% at 100μg
, 62.25% at 125μg. The IC
50
Conclusio
n:
From the
studies
, it was postulated that methanolic extract of leaf from
A. marmelos
has
significant chemopreventive activity. These
specific identities will be useful for the identification and authentication of raw
drug.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020883 |
Objective
:
The objective of the present research work
ha
d been made to evaluate the a
ntioxidant potential along with anti
-cancer
activity
of
methanolic extracts
from
the
leaf
of
A. marmelos
.
Method
s:
Standard methods for antioxidant potential in terms of DPPH and nitric oxide scavenging assay, and
anticancer
activity
in vitro
method
(Cytotoxicity
/MTT assay
and % of cell viability
) by using
MCF7 cell line.
Result
s:
Results of antioxidant efficacy reveal
ed that the IC
50
value for DPPH and nitric oxide scavenging assay was considered to be 62.032%, and
20.69% respectively. The methanolic extract of
A
. marmelos
was found to possess
enhanced
anticancer
potential against MCF7 cells. Cytotoxicity
activity of MCF7 cells
, when treated with methanolic
extract of A. marmelos
, was found to be 43.42% at 25μg
, 52.31% at 50μg,
56.31% at 75μg,
58.38% at 100μg
, 62.25% at 125μg. The IC
50
Conclusio
n:
From the
studies
, it was postulated that methanolic extract of leaf from
A. marmelos
has
significant chemopreventive activity. These
specific identities will be useful for the identification and authentication of raw
drug.
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